Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomesArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration airway analysed association Asymptomatic atraumatic biodistribution cardiovascular systems Cell consequence cynomolgus macaque cynomolgus macaques Disrupted exhibit exhibited hamster Host host susceptibility hosts identify Infection Infectious virus intranasal Lower respiratory tract lung Lung pathology methodology Microscopy Mild molecular morphology New World NHP non-human primate organelle outcome outcomes Pathogenesis pathological outcome pathology pathophysiological Post-infection Replication representing SARS-CoV-2 SARS-COV-2 infection susceptible ultrastructure Virological virus virus particle [DOI] 10.1038/s41598-022-23339-x PMC 바로가기
Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse modelArticle Published on 2022-10-282022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] acute respiratory syndrome Administered age anti-SARS-CoV-2 Antiviral Antiviral compound antiviral efficacy body weight Body weight loss caused Cell clinical development coronavirus coronavirus disease correlated COVID-19 demonstrated development dose dose-dependent manner effective Efficacy evaluated expression general treatment Health in vivo increased survival Inflammatory Intervention lung Lung inflammation Lung pathology mice mouse-adapted SARS-CoV-2 nucleocapsid protein pandemic patients with COVID-19 Post-infection protease pulmonary lesion quantified reduced reduced viral load RNA RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection Support suppressed survival target the SARS-CoV-2 titre treat Treatment Viral RNA was used were infected [DOI] 10.1093/jac/dkac257 PMC 바로가기
Longitudinal serologic and viral testing post-SARS-CoV-2 infection and post-receipt of mRNA COVID-19 vaccine in a nursing home cohort-Georgia, October 2020‒April 2021Article Published on 2022-10-272022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] administration Antibody detection Antibody Response binding binding antibody blood collection Card Cohort conducted COVID-19 COVID-19 vaccination COVID-19 vaccine Culture detectable dose evaluate evaluated Final first dose geometric IgA antibodies IgA antibody IgG IgG titer IgM antibodies immune response Immunocompromised Infection longitudinal median age mounted mRNA nasal nine nursing home observation participant polymerase chain positive Post-infection Quantitative questionnaire reverse transcription robust RT-PCR SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2-specific immune response serology specimen subsequent vaccination viral culture [DOI] 10.1371/journal.pone.0275718 PMC 바로가기
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
Importance of Intermittent Fasting Regimens and Selection of Adequate Therapy on Inflammation and Oxidative Stress in SARS-CoV-2 InfectionArticle Published on 2022-10-142022-11-16 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Adequate approach cancers cardiovascular disease chronic disease Chronic diseases communicable disease complementary coronavirus COVID-19 CVD Diabetes Mellitus dietary dietary supplements effective fasting fatty acids feasible hallmark immunomodulatory Importance Inflammation Inflammatory Intermittent intermittent fasting Modification nutraceutical obesity outcome oxidative oxidative stress Patient Polyunsaturated Post-infection quercetin Randomized controlled trial regimen SARS-CoV-2 Selection severe coronavirus disease suggested systemic Therapies time-restricted eating Treatment variant Vitamin vitamins vitamins. was performed [DOI] 10.3390/nu14204299 PMC 바로가기
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics studyArticle Published on 2022-10-142022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abuse Accelerator Antibody Response association Biomarker BNT162b2 characterized clinical trial coronavirus Course COVID-19 COVID-19 patients Critical CXCL10 cytokine dataset develop Disease progression Donor drug early IFN signaling Eiger BioPharmaceuticals enrolled Enrollment heterogeneity Host identify immune immune marker immune response immune signature immunological immunology independent individual Infection Infectious disease Inflammation machine-learning majority marker MCP-3 MCP1 Medicine memory Mild mRNA vaccination natural infection outcome Outpatient outpatients Patient Pfizer-BioNTech plasma plasma protein Post-infection predict Predictive Predictive modeling proteomics provided receiving RIG-I SARS-CoV-2 SARS-CoV-2-infected patients severe symptoms Stanford Stanford University subsequent systems immunology T cell T cell memory the antibody response trajectory transcriptomics Vaccine viral shedding Virological viruses viruses. with COVID-19 [DOI] 10.7554/eLife.77943 PMC 바로가기
In vitro inhibition of SARS-CoV-2 Infection by dry algae powdersArticle Published on 2022-10-122022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral property Arthrospira candidate Chlorella COVID-19 CPE Culture DMEM DMSO experiment fucoidan highest in viral in vitro incubated Infection inhibited investigated Post-infection purified reduced Safe Sargassum SARS-CoV-2 SARS-COV-2 infection significantly solvent supernatant TCID therapeutic Treatment Vero Cell viral inoculum Viral RNA was increased was used [DOI] 10.1038/s41598-022-22148-6 PMC 바로가기
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanismArticle Published on 2022-10-102022-11-15 Journal: Molecular Medicine [Category] 바이오마커, [키워드] Accuracy acute COVID-19 Angiogenesis AUC Biomarker Biomarkers Blood case-control study characterized Cohort COVID-19 Diagnosis diagnostics disease elevated Endoglin female Follow-up Health healthy control ICAM-1 immunoassay Inpatient Intervention investigated lack long-COVID machine machine learning marker median multiplex outpatients pathophysiological mechanism Patient patients Post-infection Sensitivity and specificity Sex significantly Specific subject Symptom targeted therapy therapeutic efficacy unique Vascular Vascular transformation. vasculature VCAM-1 VLA-4 [DOI] 10.1186/s10020-022-00548-8 PMC 바로가기
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concernArticle Published on 2022-10-032022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 antibodies antibody approach B.1.617.2 binding circulating SARS-CoV-2 variant circulating variant class COVID-19 Effect Efficacy Evidence hACE2 hamster in vitro result mice mitigate neutralization neutralization activity Neutralizing activity non-immune Post-infection provide reactive SARS-CoV-2 variant scFv selected several variant single-chain variable fragment synergistic Therapies treat Treatment variants of concern Wuhan strain [DOI] 10.1038/s41467-022-33030-4 PMC 바로가기